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Article

GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination.

Molecular and cellular biology - 1 Sept 2004

Salas-Marco Joe, Bedwell David M

Abstract excerpt

Translation termination in eukaryotes is mediated by two release factors, eRF1 and eRF3. eRF1 recognizes each of the three stop codons (UAG, UAA, and UGA) and facilitates release of the nascent polypeptide chain. eRF3 is a GTPase that stimulates the translation termination process by a poorly characterized mechanism. In this study, we examined the functional importance of GTP hydrolysis by eRF3 in Saccharomyces...

Read the complete abstract on PubMed

Topics

Base Sequence
Cell Survival
Codon, Terminator
GTP Phosphohydrolases
Guanosine Triphosphate
Mutation
Peptide Chain Termination, Translational

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Peptide Termination Factors

Protein Biosynthesis

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 15314182
DOI: 10.1128/MCB.24.17.7769-7778.2004
PMCID: PMC506980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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