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Article

Vav2 is required for cell spreading.

The Journal of cell biology - 9 Jul 2001

Marignani P A, Carpenter C L

Abstract excerpt

Vav2 is a widely expressed Rho family guanine nucleotide exchange factor highly homologous to Vav1 and Vav3. Activated versions of Vav2 are transforming, but the normal function of Vav2 and how it is regulated are not known. We investigated the pathways that regulate Vav2 exchange activity in vivo and characterized its function. Overexpression of Vav2 activates Rac as assessed by both direct measurement of...

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Identifiers

PMID: 11448999
DOI: 10.1083/jcb.200103134
PMCID: PMC2196856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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