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Article

Structural determinants for the biological activity of Vav proteins.

The Journal of biological chemistry - 22 Nov 2002

Zugaza José L, López-Lago Miguel A, Caloca María J, Dosil Mercedes, Movilla Nieves, Bustelo Xosé R

Abstract excerpt

We have used an extensive mutagenesis approach to study the specific role of the eight structural domains of Vav during both the activation and signaling steps of this Rac1 exchange factor. Our results indicate that several Vav domains (Dbl homology, pleckstrin homology, and zinc finger) are essential for all the biological activities tested, whereas others are required for discrete, cell type-specific biological...

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Source

Identifiers

PMID: 12228230
DOI: 10.1074/jbc.M208039200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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