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Article

Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity.

The Journal of biological chemistry - 18 Oct 2002

Palmby Todd R, Abe Karon, Der Channing J

Abstract excerpt

Vav family proteins are members of the Dbl family of guanine nucleotide exchange factors and activators of Rho family small GTPases. In addition to the Dbl homology (DH) domain important for guanine nucleotide exchange factor catalytic function, all Dbl family proteins contain an adjacent pleckstrin homology (PH) domain that serves to regulate DH domain activity. Although the role of the PH domain in Vav function...

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Identifiers

PMID: 12177050
DOI: 10.1074/jbc.M202641200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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