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Article

Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms

7 Aug 2018

Abstract excerpt

The bidirectional regulation of epithelial-mesenchymal transitions (EMT) is key in tumorigenesis. Rho GTPases regulate this process via canonical pathways that impinge on the stability of cell-to-cell contacts, cytoskeletal dynamics, and cell invasiveness. Here, we report that the Rho GTPase activators Vav2 and Vav3 utilize a new Rac1-dependent and miR-200c-dependent mechanism that maintains the epithelial state...

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PMID: 30087437
DOI: 10.1038/s41388-018-0433-7

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