Article
Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor.
Cellular signalling - 1 Jul 2001
Tamás P, Solti Z, Buday L
Abstract excerpt
Vav2 is a member of the Vav family that serves as guanine nucleotide exchange factors (GEFs) for the Rho family of Ras-related GTPases. Unlike Vav1, whose expression is restricted to cells of hematopoietic origin, Vav2 is broadly expressed. Recently, Vav2 has been identified as a substrate for the EGF receptor. Here, we show that in EGF-treated COS7 cells Vav2 is phosphorylated on tyrosine residues and associates...
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