Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor.

doi:10.1016/s0898-6568(01)00172-3

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Article

Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor.

Cellular signalling - 1 Jul 2001

Tamás P, Solti Z, Buday L

Abstract excerpt

Vav2 is a member of the Vav family that serves as guanine nucleotide exchange factors (GEFs) for the Rho family of Ras-related GTPases. Unlike Vav1, whose expression is restricted to cells of hematopoietic origin, Vav2 is broadly expressed. Recently, Vav2 has been identified as a substrate for the EGF receptor. Here, we show that in EGF-treated COS7 cells Vav2 is phosphorylated on tyrosine residues and associates...

Topics

Animals
COS Cells
Cell Membrane
ErbB Receptors
Green Fluorescent Proteins
Luminescent Proteins
Mutation
Oncogene Proteins
Phosphorylation
Phosphotyrosine
Recombinant Fusion Proteins
Signal Transduction

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Open in PubMed

Identifiers

PMID: 11516622
DOI: 10.1016/s0898-6568(01)00172-3

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