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Article

Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.

Experimental cell research - 1 Nov 2005

Wells Claire M, Bhavsar Parag J, Evans Iwan R, Vigorito Elena, Turner Martin, Tybulewicz Victor, Ridley Anne J

Abstract excerpt

Vav family proteins act as guanine nucleotide exchange factors for Rho family proteins, which are known to orchestrate cytoskeletal changes and cell migration in response to extracellular stimuli. Using mice deficient for Vav1, Vav2 and/or Vav3, overlapping and isoform-specific functions of the three Vav proteins have been described in various hematopoietic cell types, but their roles in regulating cell...

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Identifiers

PMID: 16137676
DOI: 10.1016/j.yexcr.2005.07.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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