Article
Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Science signaling - 15 Dec 2009
Saveliev Alexander, Vanes Lesley, Ksionda Olga, Rapley Jonathan, Smerdon Stephen J, Rittinger Katrin, Tybulewicz Victor L J
Abstract excerpt
The guanine nucleotide exchange factor (GEF) Vav1 is essential for transducing T cell antigen receptor (TCR) signals and therefore plays a critical role in the development and activation of T cells. It has been presumed that the GEF activity of Vav1 is important for its function; however, there has been no direct demonstration of this. Here, we generated mice expressing enzymatically inactive, but normally...
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