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Article

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.

BMC immunology - 12 Aug 2021

Cloutier Maryse, Fortin Jean-Simon, Thibodeau Jacques

Abstract excerpt

BACKGROUND: Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor. The newly translated Ii chains trimerize, a structural feature that is not readily understood in the context of its MHCII chaperoning function. Two segments of Ii, the luminal C-terminal region...

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Share to Antigen Presentation
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

Share to HLA-A24 Antigen

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Source

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Identifiers

PMID: 34384367
DOI: 10.1186/s12865-021-00444-6
PMCID: PMC8362237

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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