Article
Structural requirements for major histocompatibility complex class II invariant chain endocytosis and lysosomal targeting.
The Journal of biological chemistry - 7 Aug 1998
Kang S, Liang L, Parker C D, Collawn J F
Abstract excerpt
The invariant chain (Ii) targets newly synthesized major histocompatibility complex class II complexes to a lysosome-like compartment. Previously, we demonstrated that both the cytoplasmic tail (CT) and transmembrane (TM) domains of Ii were sufficient for this targeting and that the CT contains t...
Topics
- Amino Acid Sequence
- Ammonium Chloride
- Animals
- Antigens, Differentiation, B-Lymphocyte
- Chick Embryo
- Endocytosis
- Histocompatibility Antigens Class II
- Humans
- Kinetics
- Lysosomes
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Receptors, Transferrin
- Recombinant Fusion Proteins
- Structure-Activity Relationship