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Article

The mitotic spindle is required for loading of the DASH complex onto the kinetochore.

Genes & development - 15 Jan 2002

Li Yumei, Bachant Jeff, Alcasabas Annette A, Wang Yanchang, Qin Jun, Elledge Stephen J

Abstract excerpt

A role for the mitotic spindle in the maturation of the kinetochore has not been defined previously. Here we describe the isolation of a novel and conserved essential gene, ASK1, from Saccharomyces cerevisiae involved in this process. ask1 mutants display either G(2)/M arrest or segregation of DNA masses without the separation of sister chromatids, resulting in massive nondisjunction and broken spindles. Ask1...

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Identifiers

PMID: 11799062
DOI: 10.1101/gad.959402
PMCID: PMC155319

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Source receipt: pubmed, retrieved 7 Sept 2026.

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The mitotic spindle is required for loading of the DASH complex onto the kinetochore.PMID 11799062Read ↗

Implication of a novel multiprotein Dam1p complex in outer kinetochore function.Semantic proximity Read ↗

Genetic analysis of the kinetochore DASH complex reveals an antagonistic relationship with the ras/protein kinase A pathway and a novel subunit required for Ask1 association.Semantic proximity Read ↗

The fission yeast DASH complex is essential for satisfying the spindle assembly checkpoint induced by defects in the inner-kinetochore proteins.Semantic proximity Read ↗

The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation.Semantic proximity Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

Dad1p, third component of the Duo1p/Dam1p complex involved in kinetochore function and mitotic spindle integrity.Semantic proximity Read ↗

CDC2 phosphorylation of the fission yeast dis1 ensures accurate chromosome segregation.Semantic proximity Read ↗

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope.Semantic proximity Read ↗

Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.Semantic proximity Read ↗

The Arabidopsis SKP1 homolog ASK1 controls meiotic chromosome remodeling and release of chromatin from the nuclear membrane and nucleolus.Semantic proximity Read ↗

Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments.Semantic proximity Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

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