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Article

Protein complexes at the microtubule organizing center regulate bipolar spindle assembly.

Cell cycle (Georgetown, Tex.) - 1 May 2008

Rodriguez Adrianna S, Batac Joseph, Killilea Alison N, Filopei Jason, Simeonov Dimitre R, Lin Ida, Paluh Janet L

Abstract excerpt

Bipolar spindle assembly is essential to genomic stability in dividing cells. Centrosomes or spindle pole bodies duplicated earlier at G(1)/S remain adjacent until triggered at mitotic onset to become bipolar. Pole reorientation is stabilized by microtubule interdigitation but mechanistic details for bipolarity remain incomplete. To investigate the contribution of spindle pole microtubule organizing center (MTOC)...

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Identifiers

PMID: 18418055
DOI: 10.4161/cc.7.9.5808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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