Article
X-irradiation induces up-regulation of ATM gene expression in wild-type lymphoblastoid cell lines, but not in their heterozygous or homozygous ataxia-telangiectasia counterparts.
Japanese journal of cancer research : Gann - 1 Jun 2001
Hirai Y, Hayashi T, Kubo Y, Hoki Y, Arita I, Tatsumi K, Seyama T
Abstract excerpt
Ataxia-telangiectasia (AT) is an autosomal recessive disease. The relevant gene has been cloned and designated ATM. We studied the expression of both ATM mRNA and the ATM protein in unirradiated and X-irradiated EBV (Epstein-Barr virus)-transformed lymphoblastoid cell lines (LCLs) derived from do...
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