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Article

The ATM tumour suppressor gene is down‐regulated in EBV‐associated nasopharyngeal carcinoma

10 Nov 2008

Abstract excerpt

A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or...

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PMID: 19142888
DOI: 10.1002/path.2487

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