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ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes

6 Jan 2011

Abstract excerpt

Maintenance of genomic stability depends on the DNA damage response, a biologic barrier in early stages of cancer development. Failure of this response results in genomic instability and high predisposition toward lymphoma, as seen in patients with ataxia-telangiectasia mutated (ATM) dysfunction. ATM activates multiple cell-cycle checkpoints and DNA repair after DNA damage, but its influence on...

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PMID: 21209379
DOI: 10.1182/blood-2010-09-310987

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