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Article

Characterization of the mutational specificity of DNA cross-linking mutagens by the Lac+ reversion assay with Escherichia coli.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 2001

Ohta T, Ohmae S, Yamaya K, Kanemichi Y, Tokishita S, Yamagata H

Abstract excerpt

The mutational specificities of DNA cross-linking compounds such as cisplatin, transplatin, carboplatin, mitomycin C, psoralen, and 8-methoxypsoralen were investigated in lacZ reversion assay systems of Escherichia coli. Tester strains were constructed by introducing the six kinds of F' plasmids (lacI-, lacZ461, and proAB+), each of which carries a different base-substitution mutation within the lacZ gene. Each...

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PMID: 11406833
DOI: 10.1002/tcm.1015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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