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Article

Mutagenic activity of cisplatin in the lacZ plasmid-based transgenic mouse model.

Environmental and molecular mutagenesis - 1 Jan 2002

Louro Henriqueta, Silva Maria J, Boavida Maria G

Abstract excerpt

Cis-diamminedichloroplatinum (II) (cisplatin) is a well characterized antitumor drug used for the treatment of a variety of human cancers. The cytotoxicity of cisplatin is mainly mediated through the formation of DNA adducts, which are also believed to be responsible for the secondary malignancies produced by the drug. The aim of this study was to determine the in vivo mutagenic activity of cisplatin in the lacZ...

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Identifiers

PMID: 12489119
DOI: 10.1002/em.10118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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