Mutagenic activity of cisplatin in the lacZ plasmid-based transgenic mouse model.

doi:10.1002/em.10118

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Article

Mutagenic activity of cisplatin in the lacZ plasmid-based transgenic mouse model.

Environmental and molecular mutagenesis - 1 Jan 2002

Louro Henriqueta, Silva Maria J, Boavida Maria G

Abstract excerpt

Cis-diamminedichloroplatinum (II) (cisplatin) is a well characterized antitumor drug used for the treatment of a variety of human cancers. The cytotoxicity of cisplatin is mainly mediated through the formation of DNA adducts, which are also believed to be responsible for the secondary malignancies produced by the drug. The aim of this study was to determine the in vivo mutagenic activity of cisplatin in the lacZ...

Topics

Animals
Antineoplastic Agents
Cisplatin
DNA Adducts
DNA Mutational Analysis
Lac Operon
Liver
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutagens
Mutation
Plasmids

Source

Open in PubMed

Identifiers

PMID: 12489119
DOI: 10.1002/em.10118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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