Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.

doi:10.1128/jb.00126-23

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Article

Mutations in AcrR and RNA Polymerase Confer High-Level Resistance to Psoralen-UVA Irradiation.

Journal of bacteriology - 27 Jun 2023

Worley Travis K, Weber Emma A, Acott Jedidiah D, Shimpi Rahul S, Cole Jessica M, Courcelle Charmain T, Courcelle Justin

Abstract excerpt

DNA interstrand cross-links, such as those formed by psoralen-UVA irradiation, are highly toxic lesions in both humans and bacteria, with a single lesion being lethal in Escherichia coli. Despite the lack of effective repair, human cancers and bacteria can develop resistance to cross-linking treatments, although the mechanisms of resistance remain poorly defined. Here, we subjected E. coli to repeated...

Topics

Humans
Anti-Bacterial Agents
DNA
Escherichia coli
Escherichia coli Proteins
Ficusin
Mutation

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Identifiers

PMID: 37249472
DOI: 10.1128/jb.00126-23
PMCID: PMC10294641

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