Article
Mutagenicity of TCDD in Big Blue transgenic rats.
Mutation research - 1 Jul 2001
Thornton A S, Oda Y, Stuart G R, Glickman B W, de Boer J G
Abstract excerpt
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a significant environmental contaminant resulting from such industrial processes as pulp and paper production. TCDD is a suspected human carcinogen and its ability to induce cancer in laboratory rodents is well documented. Its mechanism of tumor initiation, however, is not well understood and in vitro mutagenicity studies have yielded inconsistent...
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