Article
Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele.
Neurology - 12 Jun 2001
Murphy G M, Claassen J D, DeVoss J J, Pascoe N, Taylor J, Tinklenberg J R, Yesavage J A
Abstract excerpt
The reason for differences in rate of cognitive decline in AD is unknown. The interleukin-1 alpha (IL-1 alpha) -889 *2 allele is associated with increased risk for AD. Surprisingly, in a sample of 114 patients followed for an average of 3.8 years, individuals homozygous for the IL-1 alpha -889 *1 allele declined significantly more rapidly on the Mini-Mental State Examination than did others. There was no...
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