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Article

Impaired regulation of immune responses in cognitive decline and Alzheimer's disease: lessons from genetic association studies.

Expert review of neurotherapeutics - 1 Sept 2006

Chiappelli Martina, Tumini Emanuela, Porcellini Elisa, Licastro Federico

Abstract excerpt

Altered levels of cytokines and acute-phase proteins have been described in the blood and brain of patients with Alzheimer's disease. Microglia are resident cells of the brain and metabolic upregulation of these cells may play a crucial role in the development of the neurodegeneration associated with Alzheimer's disease. Studies focusing on gene polymorphisms of molecules with immune regulatory function have...

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PMID: 17009920
DOI: 10.1586/14737175.6.9.1327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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