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Article

Association of an interleukin 1 alpha polymorphism with Alzheimer's disease.

Neurology - 22 Aug 2000

Du Y, Dodel R C, Eastwood B J, Bales K R, Gao F, Lohmüller F, Müller U, Kurz A, Zimmer R, Evans R M, Hake A, Gasser T, Oertel W H, Griffin W S, Paul S M, Farlow M R

Abstract excerpt

BACKGROUND: Retrospective epidemiologic studies suggest that individuals exposed to anti-inflammatory agents such as nonsteroidal anti-inflammatory drugs have a lower probability of developing AD as well as an older age at onset for the illness. Neuroinflammation may play an important role in the pathogenesis of AD. Interleukin 1 (IL-1), a potent proinflammatory cytokine, is colocalized immunohistochemically to...

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Identifiers

PMID: 10953177
DOI: 10.1212/wnl.55.4.480

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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