Article
Inactivation of the small GTPase Rac1 protects the liver from ischemia/reperfusion injury in the rat.
Surgery - 1 Sept 2003
Harada Nobuko, Iimuro Yuji, Nitta Takashi, Yoshida Masanori, Uchinami Hiroshi, Nishio Toshihiro, Hatano Etsuro, Yamamoto Naritaka, Yamamoto Yuzo, Yamaoka Yoshio
Abstract excerpt
BACKGROUND: In ischemia/reperfusion (I/R) injury, a massive generation of reactive oxygen species (ROS) after reperfusion is a critical factor. Rac, a member of the Rho GTPase superfamily, plays important roles in the production of ROS and activation of nuclear factor-kappaB (NF-kappaB) in vitro. However, the exact role of Rac in the ROS production and NF-kappaB activation in vivo after I/R is still obscure....
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