Article
Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production.
Shock (Augusta, Ga.) - 1 Feb 2010
Nikolaidis Nikolaos M, Gray Jerilyn K, Gurusamy Devikala, Fox William, Stuart William D, Huber Nathan, Waltz Susan E
Abstract excerpt
The Ron receptor tyrosine kinase (TK) plays a regulatory role in the inflammatory response to acute lung injury induced by intranasal administration of bacterial LPS. Previously, we have shown that mice with a targeted deletion of the TK signaling domain of the Ron receptor exhibited more severe...
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