Article
Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production.
Shock (Augusta, Ga.) - 1 Feb 2010
Nikolaidis Nikolaos M, Gray Jerilyn K, Gurusamy Devikala, Fox William, Stuart William D, Huber Nathan, Waltz Susan E
Abstract excerpt
The Ron receptor tyrosine kinase (TK) plays a regulatory role in the inflammatory response to acute lung injury induced by intranasal administration of bacterial LPS. Previously, we have shown that mice with a targeted deletion of the TK signaling domain of the Ron receptor exhibited more severe lung injury in response to intranasal LPS administration as evidenced by an increased leakage of albumin in the lungs...
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