Article
TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils.
Immunity - 27 Jan 2012
Ajibade Adebusola Alagbala, Wang Qinfu, Cui Jun, Zou Jia, Xia Xiaojun, Wang Mingjun, Tong Yanzheng, Hui Wei, Liu Dou, Su Bing, Wang Helen Y, Wang Rong-Fu
Abstract excerpt
Stringent control of NF-κB and mitogen-activated protein kinase (MAPK) signaling is critical during innate immune responses. TGF-β activated kinase-1 (TAK1) is essential for NF-κB activation in T and B cells but has precisely the opposite activity in myeloid cells. Specific deletion of TAK1 (Map3k7(ΔM/ΔM)) led to development of splenomegaly and lymphomegaly associated with neutrophilia. Compared with wild-type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.