Article
Alterations of the 16q22.1 and 16q24.3 chromosomal loci in sporadic invasive breast carcinomas: correlation with proliferative activity, ploidy and hormonal status of the tumors.
Anticancer research - 1 Jan 2000
Kouvaraki M, Gorgoulis V G, Rassidakis G Z, Liodis P, Koutroumbi E, Markopoulos C, Gogas J, Kittas C
Abstract excerpt
BACKGROUND: Breast cancer is characterized by complex genetic alterations found in multiple chromosomal regions, most commonly losses of 17p, 16q, 8p and others. A number of tumor suppressor genes mapped on these loci have been investigated in mammary tumors, whereas other gene products are of unclear function and await identification. MATERIALS AND METHODS: We analyzed the loss of heterozygosity (LOH) of two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.