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Article

Loss of heterozygosity is detected at chromosomes 1p35-36 (NB), 3p25 (VHL), 16p13 (TSC2/PKD1), and 17p13 (TP53) in microdissected apocrine carcinomas of the breast.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 1999

Lininger R A, Zhuang Z, Man Y, Park W S, Emmert-Buck M, Tavassoli F A

Abstract excerpt

INTRODUCTION: Apocrine carcinomas of the breast are an unusual special category of predominantly AR+, ER-, and PR- breast cancer, characterized by cells with abundant, eosinophilic cytoplasm and nuclei with often prominent nucleoli. To further investigate these lesions, loss of heterozygosity (LO...

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Source

Identifiers

PMID: 10619258

Genes

VHL
PKD1
TSC2
PYGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10619258-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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