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Article

Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jul 2004

Shiromani Priyattam J, Xu Man, Winston Elizabeth M, Shiromani Samara N, Gerashchenko Dmitry, Weaver David R

Abstract excerpt

In mammals, sleep is regulated by circadian and homeostatic mechanisms. The circadian component, residing in the suprachiasmatic nucleus (SCN), regulates the timing of sleep, whereas homeostatic factors determine the amount of sleep. It is believed that these two processes regulating sleep are independent because sleep amount is unchanged after SCN lesions. However, because such lesions necessarily damage...

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Identifiers

PMID: 15031135
DOI: 10.1152/ajpregu.00138.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes.PMID 15031135Read ↗

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