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Article

The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma).

1 Sept 1993

Abstract excerpt

HLA class II alleles were determined using the PCR-RFLP method in Japanese systemic sclerosis (scleroderma) patients with (n = 28) or without (n = 34) anti-topoisomerase I antibodies (anti-topo I). Either the DQB1*0601 or *0301 allele was recognized in all anti-topo I positive patients, compared with 44% of anti-topo I negative patients (P < 0.00001, relative risk [RR] > 41) or 58% of Japanese healthy control...

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Identifiers

PMID: 7690776
DOI: 10.1172/jci116703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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