Article
HLA associations in three mutually exclusive autoantibody subgroups in UK systemic sclerosis patients.
British journal of rheumatology - 1 Feb 1998
Fanning G C, Welsh K I, Bunn C, Du Bois R, Black C M
Abstract excerpt
Systemic sclerosis (SSc) is characterized by the presence of autoantibodies, mostly IgG, which target a limited set of nuclear proteins. These antinuclear antibodies (ANA) associate with disease subgroups and specific organ involvement. Here we show that there is mutual exclusivity of individual ANA in 130 UK SSc patients, confirm clinical associations with antibody profile and extend the analysis to include...
Topics
- Antibodies, Antinuclear
- Autoantigens
- Centromere Protein B
- Chromosomal Proteins, Non-Histone
- Cohort Studies
- DNA Topoisomerases, Type I
- DNA-Binding Proteins
- DNA-Directed RNA Polymerases
- Genotype
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Scleroderma, Systemic
- United Kingdom