Article
Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2020
Tiniakou Eleni, Fava Andrea, McMahan Zsuzsanna H, Guhr Tara, O'Meally Robert N, Shah Ami A, Wigley Fredrick M, Cole Robert N, Boin Francesco, Darrah Erika
Abstract excerpt
OBJECTIVE: Autoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality. Anti-topo I antibodies (ATAs) are associated with specific HLA-DRB1 alleles, and the frequency of HLA-DR-restricted topo I-specific CD4+ T cells is associated with the presence, severity, and progression of ILD. Although this strongly...
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