Article
Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency.
Biochemical and biophysical research communications - 30 Sept 2011
Xu Naihan, Libertini Silvana, Zhang Yaou, Gillespie David A
Abstract excerpt
It has been reported previously that both Cdk1 and Cdk2 phosphorylate Chk1 in a cell-cycle dependent manner. Cdk-mediated phosphorylation is required for efficient activation of Chk1 and checkpoint proficiency in response to DNA damage. Here, we demonstrate that Cdk-mediated phosphorylation is also required for replication stress induced Chk1 activation and S/M checkpoint proficiency. Re-introduction of Chk1...
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