Gain of function mutations in p53.

doi:10.1038/ng0593-42

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Article

Gain of function mutations in p53.

Nature genetics - 1 May 1993

Dittmer D, Pati S, Zambetti G, Chu S, Teresky A K, Moore M, Finlay C, Levine A J

Abstract excerpt

We report that the expression of murine or human mutant p53 proteins in cells with no endogenous p53 proteins confers new or additional phenotypes upon these cells. Mutant p53 proteins expressed in cell lines lacking p53 resulted in either enhanced tumorigenic potential in nude mice ((10)3 cells)...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Carrier Proteins
Cell Division
Cell Line
Clone Cells
Gene Expression Regulation
Genes, p53
Humans
Membrane Glycoproteins
Mice
Mice, Inbred BALB C
Mice, Nude
Mutation
Neoplasms, Experimental
Phenotype
Species Specificity
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8099841
DOI: 10.1038/ng0593-42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8099841-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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