Article
Mutant p53 gain-of-function in cancer.
Cold Spring Harbor perspectives in biology - 1 Feb 2010
Oren Moshe, Rotter Varda
Abstract excerpt
In its wild-type form, p53 is a major tumor suppressor whose function is critical for protection against cancer. Many human tumors carry missense mutations in the TP53 gene, encoding p53. Typically, the affected tumor cells accumulate excessive amounts of the mutant p53 protein. Various lines of evidence indicate that, in addition to abrogating the tumor suppressor functions of wild-type p53, the common types of...
Topics
- Alleles
- Animals
- Apoptosis
- Disease Models, Animal
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Neoplasm Metastasis
- Neoplasms