Article
Interactions of mutant p53 with DNA: guilt by association.
Oncogene - 2 Apr 2007
Kim E, Deppert W
Abstract excerpt
Since the very early days of p53 research, the gain of oncogenic activities by some mutant p53 proteins had been suspected as an important factor contributing to cancer progression. Considerable progress towards understanding the biology of mutant p53 has been made during the last years, the quintessence being the realization that the impact of mutant p53 proteins on the transcriptome of a tumor cell is much more...
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