Transcription regulation by mutant p53.

Abstract excerpt

In addition to the loss of wild-type p53 activity, a high percentage of tumor cells accumulate mutant p53 protein isoforms. Whereas the hallmark of the wild-type p53 is its tumor suppressor activities, tumor-associated mutant p53 proteins acquire novel functions enabling them to promote a large spectrum of cancer phenotypes. During the last years, it became clear that tumor-associated mutant p53 proteins are not...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Expression Regulation, Neoplastic
• Share to Mutation
• Share to Neoplasms