p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect.

Abstract excerpt

Increasing the complexity of their models, p53s are stabilized either in order to function (wt p53) or due to the loss of function (mutant p53) with acquiring a mysterious prion-like ability to drive the normal p53 into the abnormal conformation to gain new functions. As already recognized, the l...

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