Article
Hydrocarbon carcinogens evade cellular defense mechanism of G1 arrest in nontransformed and malignant lung cell lines.
Toxicology and applied pharmacology - 1 Jun 2001
Khan Q A, Anderson L M
Abstract excerpt
In previous studies using human breast carcinoma cells (MCF-7) and human colon carcinoma cells (RKO) we have shown that, in response to treatment with hydrocarbon carcinogens, these cell lines failed to undergo a p53-mediated cell cycle arrest in G1 phase; rather, the cells were accumulated in the S phase with damaged DNA, a situation that may lead to replication of DNA on a damaged template, resulting in the...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adenocarcinoma
- Adenocarcinoma, Bronchiolo-Alveolar
- Animals
- Antineoplastic Agents
- Carcinogens
- Cell Line
- Cell Transformation, Neoplastic
- Chrysenes
- DNA Damage