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Article

Nicotine overrides DNA damage-induced G1/S restriction in lung cells.

PloS one - 29 Apr 2011

Nishioka Takashi, Yamamoto Daisuke, Zhu Tongbo, Guo Jinjin, Kim Sung-Hoon, Chen Chang Yan

Abstract excerpt

As an addictive substance, nicotine has been suggested to facilitate pro-survival activities (such as anchorage-independent growth or angiogenesis) and the establishment of drug resistance to anticancer therapy. Tobacco smoking consists of a variety of carcinogens [such as benzopyrene (BP) and nitrosamine derivatives] that are able to cause DNA double strand breaks. However, the effect of nicotine on DNA...

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Identifiers

PMID: 21559516
DOI: 10.1371/journal.pone.0018619
PMCID: PMC3084701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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