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Article

Impairment of cell cycle progression by aflatoxin B1 in human cell lines.

Mutagenesis - 1 May 2002

Ricordy R, Gensabella G, Cacci E, Augusti-Tocco G

Abstract excerpt

Aflatoxin B1 is a mycotoxin produced by Aspergillus flavus and Aspergillus parasiticum, which may be present as a food contaminant. It is known to cause acute toxic effects and act as a carcinogenic agent. The carcinogenic action has been related to its ability to form unstable adducts with DNA, which represent possible mutagenic sites. On the other hand, the primary cellular target responsible for its toxic...

Topics

Aflatoxin B1
Blotting, Western
Bromodeoxyuridine
Carcinogens
Cell Cycle
Cell Line
Cyclic AMP
Flow Cytometry
Humans
Multivariate Analysis
Mutation
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Time Factors

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 11971996
DOI: 10.1093/mutage/17.3.241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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