Aflatoxin B1-induced immortalization of cultured skin fibroblasts from a patient with Li-Fraumeni syndrome.

doi:10.1093/carcin/16.1.25

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Article

Aflatoxin B1-induced immortalization of cultured skin fibroblasts from a patient with Li-Fraumeni syndrome.

Carcinogenesis - 1 Jan 1995

Tsutsui T, Fujino T, Kodama S, Tainsky M A, Boyd J, Barrett J C

Abstract excerpt

To examine the mechanisms of immortalization in human cells, normal human diploid fibroblasts (WHE-7) and skin fibroblasts from a patient with Li-Fraumeni syndrome (MDAH 087) and a mutant p53 allele were treated with aflatoxin B1 (AFB1). Exogenous metabolic activation of AFB1 with rat liver post-mitochondrial supernatant (PMS) was used and the optimal treatment conditions needed were determined by the...

Topics

Adult
Aflatoxin B1
Biotransformation
Cell Division
Cell Line
Cellular Senescence
DNA
DNA Fingerprinting
Fibroblasts
Genes, p53
Humans
Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Li-Fraumeni Syndrome

Male

Methylnitronitrosoguanidine

Mutation

Skin

Skin Physiological Phenomena

Source

Open in PubMed

Identifiers

PMID: 7834802
DOI: 10.1093/carcin/16.1.25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7834802-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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