Article
Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells.
Radiation research - 1 Jan 2001
Zhao Y L, Piao C Q, Hall E J, Hei T K
Abstract excerpt
Carcinogenesis is a multistage process with sequences of genetic events that govern the phenotypic expression of a series of transformation steps that lead to the development of metastatic cancer. To better understand the mechanisms involved in human bronchial carcinogenesis induced by alpha particles from radon, we have developed a model of neoplastic transformation based on human papillomavirus-immortalized...
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