Identification through microarray gene expression analysis of cellular responses to benzo( a )pyrene and its diol-epoxide that are dependent or independent of p53

doi:10.1093/carcin/bgm227

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Identification through microarray gene expression analysis of cellular responses to benzo( a )pyrene and its diol-epoxide that are dependent or independent of p53

17 Oct 2007

Abstract excerpt

Human colon carcinoma cells (HCT116) differing in p53 status were exposed to benzo(a)pyrene (BaP) or anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE) and their gene expression responses compared by complementary DNA microarray technology. Exposure of cells to BPDE for up to 24 h resulted in gene expression profiles more distinguishable by duration of exposure than by p53 status, although a subset of...

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Identification through microarray gene expression analysis of cellular responses to benzo( a )pyrene and its diol-epoxide that are dependent or independent of p53

Abstract excerpt

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Identification through microarray gene expression analysis of cellular responses to benzo( a )pyrene and its diol-epoxide that are dependent or independent of p53

Abstract excerpt

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