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Article

Neoplastic transformation of human cells in vitro.

Critical reviews in oncogenesis - 1 Jan 1993

Rhim J S

Abstract excerpt

Efforts to investigate the progression of events that lead normal human cells in culture to become neoplastic in response to carcinogenic agents have been aided by the development of the suitable in vitro model systems. For initial human cell transformation studies, a flat, nontumorigenic clonal line, originally derived from a human osteosarcoma (HOS), was used. When treated with chemical carcinogens such as...

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PMID: 8485202

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