Article
Transformation of human breast epithelial cells by chemical carcinogens
1 Jan 1993
Abstract excerpt
The present study was carried out to determine whether human breast epithelial cells (HBEC) are transformed by chemicals that have been proven to be carcinogenic in other model systems. A spontaneously immortalized human breast epithelial cell line, MCF-10F, was treated with dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (B[a]P), N-methyl-N-nitrosoguanidine (MNNG) or N-methyl-N-nitrosourea (NMU) for 24 h. MCF-7...
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