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Article

Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse.

Journal of autoimmunity - 1 Mar 2013

Koelsch Kristi A, Webb Ryan, Jeffries Matlock, Dozmorov Mikhail G, Frank Mark Barton, Guthridge Joel M, James Judith A, Wren Jonathan D, Sawalha Amr H

Abstract excerpt

Genetic polymorphism in MECP2/IRAK1 on chromosome Xq28 is a confirmed and replicated susceptibility locus for lupus. High linkage disequilibrium in this locus suggests that both MECP2 and IRAK1 are candidate genes for the disease. DNA methylation changes in lupus T cells play a central role in the pathogenesis of lupus, and MeCp-2 (encoded by MECP2) is a master regulator of gene expression and is also known to...

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Source

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Identifiers

PMID: 23428850
DOI: 10.1016/j.jaut.2012.12.012
PMCID: PMC3622940

Genes

MECP2
IRAK1
BST2
DNMT1
IFI6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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