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Article

Epigenetics, aging, and autoimmunity

1 Jan 2008

Abstract excerpt

Immune senescence is associated with a decline in T- and B-cell immune responses. It is, therefore, perhaps surprising that aging is linked to the appearance of serological and clinical autoimmunity. Here we review the mechanisms that contribute to the increase in inflammatory and autoimmune responses in aging. The bulk of this review will focus on aging-associated changes in epigenetic mechanisms, and in...

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PMID: 18432411
DOI: 10.1080/08916930802024889

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