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Revisiting the genomic hypomethylation hypothesis of aging

24 Jan 2018

Abstract excerpt

The genomic hypomethylation hypothesis of aging proposes that an overall decrease in global DNA methylation occurs with age, and it has been argued that the decrease in global DNA methylation could be an important factor in aging, resulting in the relaxation of gene expression regulation and abnormal gene expression. Since it was initially observed that DNA methylation decreased with age in 1974, 16 articles have...

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PMID: 29363785
DOI: 10.1111/nyas.13533

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