Article
Tumor necrosis factor-alpha deficiency retards early fatty-streak lesion by influencing the expression of inflammatory factors in apoE-null mice.
Molecular genetics and metabolism - 1 Apr 2009
Xiao Ning, Yin Miao, Zhang Liang, Qu Xuebin, Du Hui, Sun Xiaoming, Mao Liufeng, Ren Guocheng, Zhang Cong, Geng Yue, An Liguo, Pan Jie
Abstract excerpt
Tumor necrosis factor-alpha (TNF-alpha), a key inflammatory cytokine, plays an important role in atherosclerosis. However, its precise characters in primary stage of the disease remain unclear. To assess the influence of TNF-alpha on inflammatory factors in aorta and liver in apoE and TNF-alpha double mutant (AT) mice, a comparative study on early fatty-streak lesion, the mRNA level of target gene in aorta and...
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