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Article

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse.

Nature immunology - 1 Dec 2004

Gerdes Tobias, Wabl Matthias

Abstract excerpt

Lymphocytes typically express only one functional antigen receptor, a restriction contributed to by allelic exclusion. Here we have analyzed B lymphocyte development in offspring of a mouse generated by nuclear transfer using a single donor B lymphocyte. In this mouse, all immunoglobulin alleles were inherited as found in the donor lymphocyte. This donor cell had two rearranged immunoglobulin light chain alleles,...

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, B-Lymphocyte

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Source

Identifiers

PMID: 15516926
DOI: 10.1038/ni1133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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